کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481366 1398100 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concentrated polymer brush-modified silica particle coating confers biofouling-resistance on modified materials
ترجمه فارسی عنوان
پوشش ذرات سیلیس اصلاح شده توسط پلیمر حاوی مقاومت ضد زنگ در مواد اصلاح شده است
کلمات کلیدی
برس پلیمری متمرکز، انتقال اتوم پلیمریزاسیون رادیکال، نانوذرات سیلیکا، اصلاح سطح، جذب پروتئین، چسبندگی سلولی،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- A simple and versatile method of non-biofouling coating using polymer brush modified silica particles
- The coatings were easily cross-linked by ultraviolet irradiation or heating.
- All the coatings showed excellent protein repellency and cell resistance.

Biofouling, an undesired adsorption of biological material to otherwise inert surfaces, is detrimental in medical, pharmaceutical, and other sectors. Concentrated polymer brushes (CPB) confer non-biofouling properties on modified surfaces but are cumbersome to fabricate. Here, a simple and versatile method of fabricating non-biofouling coatings for various substrates was developed using CPB-modified silica nanoparticles (SiPs). Concentrated poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) brushes were grafted on SiPs by surface-initiated atom transfer radical polymerization. CPB-SiPs were spin-coated onto silicon wafers or quartz crystal microbalance (QCM) sensor chips with phenyl azido cross-linkers. SiP cross-linking was then performed by ultra violet irradiation for 20 s, or by heating at 120 °C for 12 h. Protein adsorption to coatings was studied by QCM approach and human umbilical vein endothelial cell adhesion to coatings was examined. SiP to cross-linker weight ratios were varied from 2.0/0.5 to 9.0/0.5 (wt/wt%) and the coatings almost completely suppressed protein adsorption and cell adhesion to treated surfaces. The coating was also applied to polymeric films, rendering these materials biofouling-resistant.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 70, Part 1, 1 January 2017, Pages 272-277
نویسندگان
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