Aptamer-Based electrochemiluminescent detection of MCF-7 cancer cells based on carbon quantum dots coated mesoporous silica nanoparticles

- Aptamers have many advantages over antibodies, such as low molecular weight, easy but reproducible production and low cost.
- Mesoporous silica nanoparticles (MSNs) were prepared to load more CQDs for signal amplification which has a large surface area and high pore volume, ordered porous channels, a uniform and tunable pore structure, and a great diversity in surface functionalization
- 3D-GR@AuNPs was prepared as biointerface for the immobilization of cancer cells due to their good biological compatibility, excellent conductivity and large surface area.
- This new aptasensor may be quite promising, with potential broad applications in cancer early diagnosis due to the excellent analytical performance.