Nickel-catalyzed direct C–H arylation of unactivated arenes with aryl halides

Ni(OAc)2·4H2O could catalyze direct C–H arylation of unactivated arenes with aryl halides in presence of 1,10-phenanthroline without using additives.

Readily available Ni(OAc)2·4H2O could catalyze direct C–H arylation of unactivated arenes with aryl bromides/iodides in presence of 1,10-phenanthroline as the ligand without using any additives. This protocol makes C–H arylation more practical and useful.Figure optionsDownload high-quality image (100 K)Download as PowerPoint slideHighlights
► Direct C–H arylation.
► Coupling of unactivated arenes with aryl halides.
► Readily available Ni(OAc)2·4H2O.
► Without using any additives.