کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6662368 | 1426570 | 2017 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel electrochemical sensor based on electropolymerized molecularly imprinted poly(aniline-co-anthranilic acid) for sensitive detection of amlodipine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel voltammetric sensor based on molecularly imprinted poly(aniline-co-anthranilic acid) for determination of amlodipine (AML) was developed. The sensor was prepared by electrocopolymerization of aniline and anthranilic acid in the presence of AML molecules and perchloric acid onto a glassy carbon electrode (GCE) using cyclic voltammetry (CV). Several parameters affecting the performance of the imprinted (MIP) and non-imprinted films (NIP) were optimized. Under optimized operational conditions, the proposed MIP/GCE sensor exhibits two distinct linear responses ranging from 0.01 nM to 0.08 nM and 0.3 nM to 8.0 nM respectively with a LOD (3Ï/m) of 2.66 pM. The precision (RSD, n = 6) of the method for intra and inter-days was found to be 0.65% and 1.68% respectively. The selectivity of the MIP/GCE sensor against AML was investigated in the presence of various interfering molecules. The proposed sensor was successfully applied for the detection of AML in pharmaceuticals, human urine, human serum and plasma. The proposed MIP/GCE sensor appeared to be suitable for sensitive and precise quantification of AML in several matrices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 805, 15 November 2017, Pages 133-145
Journal: Journal of Electroanalytical Chemistry - Volume 805, 15 November 2017, Pages 133-145
نویسندگان
Hajer Hrichi, Lotfi Monser, Nafaâ Adhoum,