کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
67769 | 48494 | 2007 | 7 صفحه PDF | دانلود رایگان |
Methyl (S)-β-hydroxybutyrate, the important chiral building block for organic synthesis was produced in high yield from the methoxycarbonylation of (S)-propylene oxide ((S)-PO) using a catalytic system consisting of dicobalt octacarbonyl [Co2(CO)8] and pyrazole. The effects of different additives, temperature and CO pressure were investigated. The reaction was greatly influenced by the variation of temperature, both the conversion of (S)-PO and the selectivity of methyl (S)-β-hydroxybutyrate decreased with increasing temperature (above 80 °C). Nevertheless, the enantiomeric excess (ee) of methyl (S)-β-hydroxybutyrate is independent of the parameter of reaction temperature, no racemization reaction takes place even the reaction temperature reaches 150 °C. A possible process for the formation of ethers and diethers was presented. The reaction has a bright future in an industrial scale.
Methyl (S)-β-hydroxybutyrate was produced in high yield from the methoxycarbonylation of (S)-propylene oxide ((S)-PO) using a catalytic system consisting of dicobalt octacarbonyl [Co2(CO)8] and pyrazole in methanol. The effects of different additives, temperature and CO pressure were investigated. The reaction was greatly influenced by the variation of temperature, both the conversion of (S)-PO and the selectivity of methyl (S)-β-hydroxybutyrate decreased with increasing temperature (above 80 °C). Nevertheless, the enantiomeric excess (ee) of methyl (S)-β-hydroxybutyrate is independent of the parameters of reaction temperature, no racemization reaction takes place even the reaction temperature reaches 150 °C. The reaction can be extended to synthesize different β-hydroxybutyrates. The reaction will have a bright future in an industrial scale. Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 269, Issues 1–2, 18 May 2007, Pages 97–103