کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6810771 | 1433621 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered connectivity among emotion-related brain regions during short-term memory in Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
A PET study of patients with Alzheimer's disease (AD) engaged in a delayed match-to-sample face recognition task revealed that performance declines as a function of increasing delay, a pattern accompanied by reduced functional connectivity of prefrontal cortex but increased connectivity of the left amygdala. Here, we characterize the changes in interactions within this amygdalar circuit across the memory delays using structural equation modeling. The magnitude of effective connections was found to be much greater in the patients than in the controls, notably from the left amygdala to left inferior prefrontal cortex, which, in turn, influenced its right homologue. The influence from the amygdala to the left hippocampus, in contrast, was not strong in either group. We interpret this pattern of interactions as possibly reflecting the compensatory recruitment of a dynamic neural network, perhaps involved in implicit emotional processing, in the context of a faulty executive maintenance and retrieval system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 31, Issue 5, May 2010, Pages 780-786
Journal: Neurobiology of Aging - Volume 31, Issue 5, May 2010, Pages 780-786
نویسندگان
R. Shayna Rosenbaum, Maura L. Furey, Barry Horwitz, Cheryl L. Grady,