کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6811567 | 1433783 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-3, symptoms and cognitive deficits in first-episode drug-naïve and chronic medicated schizophrenia
ترجمه فارسی عنوان
علائم و اختلالات شناختی در بیماران مبتلا به اسکیزوفرنیا
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کلمات کلیدی
جنون جوانی، اینترلوکین-3، عملکرد عصبی شناختی، سیتوکین ها، سیستم ایمنی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Previous studies consistently showed that IL-3 signaling may be involved in the pathophysiology of schizophrenia. However, investigations of associations between IL-3 and the neurocognitive impairments are lacking, including the study of how this may vary with stage of illness. We recruited 45 first-episode drug-naïve (FE-Sz), 35 chronic medicated schizophrenia (Ch-Sz) and 40 healthy controls (HC) and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum IL-3. Altered serum IL-3 levels were found in both patient groups compared with HC group (both pâ¯<â¯0.001). There were significantly lower neurocognitive scores on the RBANS and nearly all of its five subscales, except for Visuospatial/Constructional index in both FE-Sz and Ch-Sz patients vs healthy controls. Moreover, a significant reduction in Immediate memory index (pâ¯=â¯0.021) and a trend-level reduction in RBANS total score (pâ¯=â¯0.094) in Ch-Sz than FE-Sz patients. Interestingly, there was a significant negative correlation between IL-3 and the Immediate memory index only in Ch-Sz patients (pâ¯=â¯0.03). Our findings showed that neurocognitive impairments present in schizophrenia emerge during the first episode with further diminished functioning with disease progression, and IL-3 may be involved in the immediate memory deficits in the chronic phase of schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 263, May 2018, Pages 147-153
Journal: Psychiatry Research - Volume 263, May 2018, Pages 147-153
نویسندگان
Mei-Hong Xiu, Dong Wang, Song Chen, Xiang-Dong Du, Da-Chun Chen, Nan Chen, Yue-Chan Wang, Guangzhong Yin, Yingyang Zhang, Yun-Long Tan, Raymond Y. Cho, Jair C. Soares, Xiang-Yang Zhang,