کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
68286 | 48510 | 2008 | 7 صفحه PDF | دانلود رایگان |
Lipases were shown to catalyze acylation of various sulfonamides using water or ionic liquids (ILs) as solvents. Ionic liquids that were used include [bmim][PF6], [bmim][N(Tf)2], and [bmim][BF4] (where bmim = 1-butyl-3-methylimidazolium, PF6 = hexafluorophosphate, N(Tf)2 = bis(trifluoromethylsulfonyl)imide, and BF4 = tetrafluoroborate). As a function of the lipase nature the ionic liquid can be or not a suitable solvent for this reaction. Therefore, it may be stated that an optimization of the process implies a molar ratio of 1:3, the use of lipase PS Amano as catalyst and the use of [bmim][N(Tf)2] ionic liquid as solvent. A comparison of the systems shows that the reactivity of the enzyme in [bmim][N(Tf)2] ionic liquid was generally lower than in water but the selectivity to monoacylated sulfonamide was always 100%.
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Journal: Journal of Molecular Catalysis A: Chemical - Volume 279, Issue 2, 18 January 2008, Pages 223–229