کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7138890 | 1462017 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A biodegradable porous silicon and polymeric hybrid probe for electrical neural signal recording
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper reports on a novel design and fabrication strategy to develop a hybrid porous silicon (PSi)-polyimide-based neural interface probe. The PSi is soluble in the tissue matrix, leaving the flexible polyimide shank inside the tissue as a permanent probe-implant. The flexibility of the PSi-dissolved polyimide shank is possible to reduce the tissue response, resulting from the probe-implant. In-vitro degradation experiment was conducted in phosphate buffer solution (PBS), pH 7.4, at 37â¯Â°C. The PSi with over 50% porosity was dissolved in less than 6â¯days. The electrode contacts were made of Au or Pt; impedance measurements gave values of 6.83â¯MΩ and 656â¯kΩ @1â¯kHz, respectively. The minimum critical bucking force among the fabricated probes was tested to be 71 mN, corresponding to the highest porosities of 70% and 5â¯mm shank length. Assessment of the cell viability was done using mouse fibroblast cell line, indicating that there was no sign of obvious cell lysis and reduction of cell growth on the device surface. Lastly, the functionality of the probe was proved by successful implantation in rat cortex. The local field potential action spikes were recorded with ±40â¯Î¼V peak and signal to noise ratio of 7.8.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 272, 1 November 2018, Pages 314-323
Journal: Sensors and Actuators B: Chemical - Volume 272, 1 November 2018, Pages 314-323
نویسندگان
Ning Xue, Deheng Wang, Chunxiu Liu, Zunji Ke, Paz Elia, Tong Li, Cheng Chi, Yuhua Cheng, Jianhai Sun,