کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7139183 | 1462019 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine
ترجمه فارسی عنوان
تسریع فعالیت پراکسیداز مانند نانوذرات طلا با استفاده از مشتقات پورین و کاربرد آن برای نظارت بر خون مخفی در ادرار
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کلمات کلیدی
نانوزیمه، نانوذرات طلا، پراکسیداز، پورین، گلبول قرمز،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Gold nanoparticles (AuNPs) is an important kind of nanozymes and a variety of its artificial enzymatic activities have been reported, such as oxidase, peroxidase, and superoxide dismutase. The DNA with poly purine-modified AuNPs shows an enhancement peroxidase activity compared with poly pyrimidine-modified AuNPs. In this work, purine derivatives are modified on the surface of AuNPs. The peroxidase-like activity of AuNPs is dependent on the chemical structure of the molecules capped on the surface. We find that ferric ions can accelerate the mimic enzymatic ability of 2, 6-diaminopurine (DAP) modified AuNPs. The enhanced catalytic activity comes from the synergistic reaction of AuNPs and ferric ions. The cooperative system can be applied to measure hemoglobin and red blood cells in urine with better sensitivity. Generally, there is no or few red blood cells in human urine. The presence of blood in the urine is closely related with serious diseases, for example chronic nephrotic syndrome and urinary system tumors. Compared the commercial urine test paper, the method based on DAP-AuNPs has a good sensitivity and wider quantitative range and will be helpful to do urine test at home.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 270, 1 October 2018, Pages 443-451
Journal: Sensors and Actuators B: Chemical - Volume 270, 1 October 2018, Pages 443-451
نویسندگان
Yehui Wu, Yuzhi Chen, Yawen Li, Jia Huang, Hao Yu, Zhuo Wang,