Design and characterization of microcapsules-integrated collagen matrixes as multifunctional three-dimensional scaffolds for soft tissue engineering

- 3D collagen scaffolds with charged microcapsules were developed by a facile method.
- Stimuli responsive biodegradable multilayer microcapsules were synthesized.
- Scaffolds with microcapsules showed mechanical properties similar to pristine scaffolds.
- Scaffolds could stably retain the microcapsules over long incubation time.
- Microcapsules-integrated scaffolds fully retain their original physical properties.