کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7236137 | 1471091 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells
ترجمه فارسی عنوان
فشار مکانیکی القاء سیگنال فسفو پروتئومیک در سلول های عضله صاف رحم
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کلمات کلیدی
پروتئومیکس، کار، فسفریلاسیون، زودرس رحم،
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
Mechanical strain associated with the expanding uterus correlates with increased preterm birth rates. Mechanical signals result in a cascading network of protein phosphorylation events. These signals direct cellular activities and may lead to changes in contractile phenotype and calcium signaling. In this study, the complete phospho-proteome of uterine smooth muscle cells subjected to mechanical strain for 5â¯min was compared to un-strained controls. Statistically significant, differential phosphorylation events were annotated by Ingenuity Pathway Analysis to elucidate mechanically induced phosphorylation networks. Mechanical strain leads to the direct activation of ERK1/2, HSPB1, and MYL9, in addition to phosphorylation of PAK2, vimentin, DOCK1, PPP1R12A, and PTPN11 at previously unannotated sites. These results suggest a novel network reaction to mechanical strain and reveal proteins that participate in the activation of contractile mechanisms leading to preterm labor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 73, 17 May 2018, Pages 99-107
Journal: Journal of Biomechanics - Volume 73, 17 May 2018, Pages 99-107
نویسندگان
Christian Copley Salem, Craig Ulrich, David Quilici, Karen Schlauch, Iain L.O. Buxton, Heather Burkin,