Nano composite system based on fullerene-functionalized carbon nanotubes for simultaneous determination of levodopa and acetaminophen

• The C60–CNT composite was used in the construction a voltammetric sensor.
• Determination of LD in the presence of AC was performed.
• The modified electrode has good detection limit and wide linear range.

In this paper we report an electrochemical sensor based on fullerene (C60)-functionalized carbon nanotubes composite for the sensitive determination of the levodopa (LD) and acetaminophen (AC). A modified electrode by fullerene-functionalized carbon nanotubes (CNTs) composite has been fabricated and its electrochemical behavior was investigated by cyclic voltammetry, chronoamperometry and differential pulse voltammograms. The modified electrode shows electrocatalytic activity toward LD oxidation in phosphate buffer solution (pH 7.0) with a reduction of the overpotential of about 270 mV and an increase in peak current. These conditions are sufficient to allow determination of LD and AC in the samples at fullerene-functionalized carbon nanotubes composite. The differential pulse voltammetry data showed that the obtained anodic peak currents were linearly dependent on the LD concentrations in the range of 0.5–2000 μM, with the detection limit of 0.035 μM. The prepared electrode was successfully applied for the determination of LD and AC in real samples.

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