کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7298831 | 1475124 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Running exercise mitigates the negative consequences of chronic stress on dorsal hippocampal long-term potentiation in male mice
ترجمه فارسی عنوان
تمرین در حال اجرا، پیامدهای منفی استرس مزمن را در طولانی شدن انقباض پشتی هیپوکامپ در موشهای نر کاهش می دهد
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کلمات کلیدی
AMPKSNSRT-qPCREWSENSSWSAMPAN-methyl-d-aspartateNMDABDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز long term depression - افسردگی بلند مدتlong term potentiation - تقویت طولانی مدتLTP - تقویت طولانی مدت یا LTP Brain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزLTD - محدودdorsal hippocampus - هیپوکامپ پشتیreverse transcriptase quantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی واکنش معکوسadenosine monophosphate-activated protein kinase - پروتئین کیناز فعال شده با آدنوزین مونوفسفاتCorticosterone - کورتیکوسترونMineralocorticoid receptor - گیرنده مینرالوکورتیکوئید glucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated, and exercise positively correlated to LTP induction, we examined whether exercise could mitigate the negative consequences of stress on LTP when co-occurring with stress. Mice were divided into four groups: sedentary no stress, exercise no stress, exercise with stress, and sedentary with stress. Field electrophysiology performed on brain slices confirmed that stress alone significantly reduced dorsal CA1 hippocampal LTP and exercise alone increased LTP compared to controls. Exercise with stress mice exhibited LTP that was significantly greater than mice undergoing stress alone but were not different from sedentary no stress mice. An ELISA illustrated increased corticosterone in stressed mice compared to no stress mice. In addition, a radial arm maze was used to examine behavioral changes in memory during 6â¯weeks of stress and/or exercise. Exercised mice groups made fewer errors in week 2. RT-qPCR was used to examine the mRNA expression of components in the stress and exercise pathways in the four groups. Significant changes in the expression of the following targets were detected: BDNF, TrkB, glucocorticoid, mineralocorticoid, and dopamine 5 receptors. Collectively, exercise can mitigate some of the negative impact stress has on hippocampal function when both occur concurrently.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 149, March 2018, Pages 28-38
Journal: Neurobiology of Learning and Memory - Volume 149, March 2018, Pages 28-38
نویسندگان
Roxanne M. Miller, David Marriott, Jacob Trotter, Tyler Hammond, Dane Lyman, Timothy Call, Bethany Walker, Nathanael Christensen, Deson Haynie, Zoie Badura, Morgan Homan, Jeffrey G. Edwards,