کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7301606 1475280 2018 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preclinical models of conduct disorder - principles and pharmacologic perspectives
ترجمه فارسی عنوان
مدلهای پیش از موعد اختلال رفتار - اصول و دیدگاههای دارویی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
The translational value of preclinical research was recently enhanced by abnormal aggression models, which focus on deviant behaviors induced by the exposure of rodents to etiological factors of aggression-related psychopathologies. Prompted by similar trials in other psychiatric disorders, here we investigate models of abnormal aggression from the perspective of DSM5 criteria. After proposing principles based on which analogies can be established between psychopathology symptoms and rodent behavioral dysfunctions, we show that rodents submitted to abnormal aggression models fulfill basic criteria of aggression-related psychopathologies; moreover, some models can be considered specific to particular disorders e.g. conduct disorder. We also show that abnormal and species-typical aggressions differ in terms of both brain mechanisms and pharmacological responsiveness, which mimics differences observed in psychiatric disorders. We conclude that evaluating abnormal aggression models from a DSM5 perspective is not only possible but also worthwhile, and such models may contribute to the development of novel treatment strategies not only for aggression as a symptom but also for specific aggression-related disorders or multi-symptom clusters at least.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 91, August 2018, Pages 112-120
نویسندگان
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