کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7302911 | 1475305 | 2016 | 64 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
ترجمه فارسی عنوان
درک اوتیسم و سایر اختلالات عصبی توسعه با استفاده از مدل های تحلیلی عصبی رفتاری تجربی
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کلمات کلیدی
اختلال عصبی ارگانیسم مدل، مدل تجربی، مطالعه پیشآزمون، تحقیقات ترجمه ای،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 65, June 2016, Pages 292-312
Journal: Neuroscience & Biobehavioral Reviews - Volume 65, June 2016, Pages 292-312
نویسندگان
Judith R. Homberg, Evan J. Kyzar, Michael Nguyen, William H. Norton, Julian Pittman, Manoj K. Poudel, Siddharth Gaikwad, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Maria Luisa Scattoni, Jeremy F.P. Ullman, David M. Diamond, Aleksandra A. Kaluyeva,