کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7313873 | 1475461 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Atypical processing of voice sounds in infants at risk for autism spectrum disorder
ترجمه فارسی عنوان
پردازش غیرمعمول صدای صدا در نوزادان در معرض خطر ابتلا به اختلال طیف اوتیسم است
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کلمات کلیدی
HRFHaemodynamic response functionAutism spectrum disorder - اختلالات طیف اوتیسم گروهیAutism - اوتیسم یا درخودماندگیBrain imaging - تصویربرداری از مغزfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیSocial interaction - تعامل اجتماعیInfant development - توسعه نوزادانHigh risk - ریسک بالاLow risk - ریسک کمASD - نقص سپتوم یا دیوارهی دهلیزیVoice processing - پردازش صوتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Adults diagnosed with autism spectrum disorder (ASD) show a reduced sensitivity (degree of selective response) to social stimuli such as human voices. In order to determine whether this reduced sensitivity is a consequence of years of poor social interaction and communication or is present prior to significant experience, we used functional MRI to examine cortical sensitivity to auditory stimuli in infants at high familial risk for later emerging ASD (HR group, NÂ =Â 15), and compared this to infants with no family history of ASD (LR group, NÂ =Â 18). The infants (aged between 4 and 7 months) were presented with voice and environmental sounds while asleep in the scanner and their behaviour was also examined in the context of observed parent-infant interaction. Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not. Similarly, LR infants showed stronger sensitivity than HR infants to sad vocalisations in the right fusiform gyrus and left hippocampus. Also, in the HR group only, there was an association between each infant's degree of engagement during social interaction and the degree of voice sensitivity in key cortical regions. These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence. Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cortex - Volume 71, October 2015, Pages 122-133
Journal: Cortex - Volume 71, October 2015, Pages 122-133
نویسندگان
Anna Blasi, Sarah Lloyd-Fox, Vaheshta Sethna, Michael J. Brammer, Evelyne Mercure, Lynne Murray, Steven C.R. Williams, Andrew Simmons, Declan G.M. Murphy, Mark H. Johnson,