A two-photon fluorescent turn-on probe for palladium imaging in living tissues

• The first two-photon fluorescent probe for sensing Pd(II) was constructed.
• The probe is suitable for Pd(II) imaging in living cells and tissues.
• The probe was capable of detecting Pd(II) up to 180 μm depth in live tissues.

We have rationally constructed the first two-photon fluorescence palladium probe based on the GCTPOC two-photon fluorescent dye and deprotection of aryl propargyl ethers by palladium. The probe GCTPOC-Pd displayed a 100-fold enhancement turn-on to palladium species with high sensitivity and selectivity. Additionally, the novel GCTPOC-Pd probe is suitable for fluorescence imaging of palladium in living cells and tissues.

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