کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7625382 | 1494558 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The predominant milk oligosaccharide 6â²-sialyllactose reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CFUDMEMFBSHMOMICTLR2Human milk oligosaccharides - الیگوساکارید های انسانی شیرMilk oligosaccharides - الیگوساکارید های شیرMinimum inhibitory concentration - حداقل غلظت مهاریBacterial invasion - حمله باکتریاییfetal bovine serum - سرم جنین گاوPseudomonas aeruginosa - سودوموناس آئروژینوزاCystic fibrosis - فیبروز کیستیکDulbecco’s modified eagle’s medium - محیط عقاب اصلاح شده Dulbeccocolony forming unit - کلنی واحد تشکیلToll-like receptor 2 - گیرنده تله مانند 2
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pseudomonas aeruginosa is an opportunistic pathogen, often responsible for nosocomial infections and chronic lung infections in cystic fibrosis patients. The antibiotic resistance associated with this pathogen makes it difficult to eradicate. Therefore, the discovery of molecules capable of reducing the morbidity and mortality associated with this infection is appealing. P. aeruginosa pathogenicity is associated with both adhesion and invasion of epithelia. Previous studies have shown that predominant milk oligosaccharides, 6â²-sialyllactose (6-SL) and 3â²-sialyllactose (3-SL), are able to inhibit P. aeruginosa adhesion to human pneumocytes. Here, we demonstrate that 6-SL, at its estimated systemic concentrations i.e. what infants are likely to ingest during breastfeeding, is effective in reducing the pneumocytes invasion of both P. aeruginosa mucoid and non mucoid strains, the effect being concentration-dependent in the case of the latter. This study shows the potential of milk oligosaccharides as ingredients in functional foods aimed at lowering the incidence of infectious diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 6, January 2014, Pages 367-373
Journal: Journal of Functional Foods - Volume 6, January 2014, Pages 367-373
نویسندگان
Mariarosaria Marotta, Joseph Thomas Ryan, Rita M. Hickey,