Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls

► Combination of depletion, IMAC and nanoLC-MSE was used to analyse serum samples. ► Non-pooled serum samples from 20 schizophrenia patients and 20 controls were investigated individually. ► Identification of 72 phosphoproteins with altered phosphorylation patterns. ► Most showed altered phosphorylation, without change in protein concentration. ► Specific examples of clinical use of changed phosphoproteins.