Proteome alterations in response to aristolochic acids in experimental animal model

► We studied proteome changes associated with aristolochic acids (AA) exposure in mice. ► Early proteome alterations were examined in mice urine, plasma and kidney tissue. ► Several proteins were differentially expressed in both AA exposed and control mice. ► These proteins are consistent with renal pathogenesis of endotoxicity and cancer. ► Several proteins were identified as possible biomarker candidates for AA nephropathy.