کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7638402 1494804 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identifying mutated proteins secreted by colon cancer cell lines using mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Identifying mutated proteins secreted by colon cancer cell lines using mass spectrometry
چکیده انگلیسی
► We developed a novel method - iMASp (identification of Mutated And Secreted proteins). ► Human Protein Mutant Database (HPMD) has 171,919 known disease mutations and SNPs. ► We detected 112 protein mutations from 18 colorectal cancer cell line secretome. ► Protein mutations identified by MS were verified by RT-PCR and cDNA sequencing. ► Three mutations were common between colorectal tissue and cell line secretome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 76, 5 December 2012, Pages 141-149
نویسندگان
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