Development and analytical validation of a multivariate calibration method for determination of amoxicillin in suspension formulations by near infrared spectroscopy

► We develop a NIR-PLS method for determining amoxicillin in suspension formulations. ► This method is simpler and eight times faster than the USP chromatographic one. ► A multivariate analytical validation is carried out. ► We harmonize multivariate concepts with the more traditional univariate ones.