Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy

Complexation of the antitubercular prodrugs isoniazid and pyrazinamide with [FeII(CN)5]3- as a strategy to generate, through H2O2 activation, the corresponding active metabolites and overcome Mycobacterium tuberculosis resistance.147