Oxidative stress sensing by the iron-sulfur cluster in the transcription factor, SoxR

The [2Fe-2S] transcription factor SoxR functions as a bacterial sensor of oxidative stress. The redox-induced structural changes in SoxR are communicated to the DNA-binding domain, leading to distortion in the target promoter. The direct reaction of O2− is an important mechanism for Escherichia coli SoxR signaling.