Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies

Modeled mode of binding of most active compound 9 (Magenta) into the active site of urease from Bacillus pasteurii. (A) Ribbon form. (B) Docked conformation showing interactions with Ni bi-center. (C) Surface form.