Voglibose-inspired synthesis of new potent α-glucosidase inhibitors N-1,3-dihydroxypropylaminocyclitols

- N-1,3-dihydroxypropylaminocyclitols were synthesized from natural (+)-proto-quercitol through reductive amination.
- The target compounds were potent competitive inhibitors against rat intestinal maltase and sucrase with submicromolar Ki values.
- Docking study indicated that the cyclohexane rings of voglibose and the synthesized compounds are tilted relative to that of miglitol.