Differential O-3/O-4 selectivity in the glycosylation of N-dimethylmaleoyl-protected hexosamine acceptors: effect of a conformationally armed (superarmed) glycosyl donor

- The reactivity of both anomers of 6-O-protected allosamine and glucosamine acceptors with a superarmed donor was assessed.
- Glucosamine derivatives react with the same selectivity as with disarmed donors, i.e. driven by electronic effects.
- Allosamine derivatives react exclusively by the equatorial O-4, i.e. driven by steric factors.