Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents

A new series of C12-sphinganine derived 1,2,3-triazole analogs 2(a-f) were designed and synthesized for the first time. These scaffolds exhibited promising antimicrobial, antifungal and anti-biofilm activities.208