Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives

► Licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid) derivation at C5. ► Increased selectivity for MCF-7 cells especially determined for 2-oxoethyl benzoate derivatives. ► Modifications significantly reduced anti-inflammatory effects in vitro and in vivo.