کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7846979 1508793 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Doxorubicin-conjugated pH-responsive gold nanorods for combined photothermal therapy and chemotherapy of cancer
ترجمه فارسی عنوان
نانوسایل طلای زرد طلایی با دوزوروبایسین-کانژوگه برای ترکیب فتوترمال و شیمی درمانی سرطان
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
Cancer chemotherapy can be hindered by drug resistance which leads to lower drug efficiency. Here, we have developed a drug delivery system that tethers doxorubicin to the surface of gold nanorods via a pH-sensitive linkage (AuNRs@DOX), for a combined photothermal and chemical therapy for cancer. First, AuNRs@DOX is ingested by HepG2 liver cancer cells. After endocytosis, the acidic pH triggers the release of doxorubicin, which leads to chemotherapeutic effects. The gold nanorods are not only carriers of DOX, but also photothermal conversion agents. In the presence of an 808 nm near-infrared laser, AuNRs@DOX significantly enhance the cytotoxicity of doxorubicin via the photothermal effect, which induces elevated apoptosis of hepG2 cancer cells, leading to better therapeutic effects in vitro and in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioactive Materials - Volume 3, Issue 3, September 2018, Pages 347-354
نویسندگان
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