Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration

Polymeric microparticles delivered FGF1 and NRG1 to ischemic myocardium. This strategy contributed to global myocardial function by inhibiting cardiac remodeling, promoting revascularization, inducing cardiac proliferation, and eliciting stem cell recruitment.205