کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7866321 | 1509133 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery
ترجمه فارسی عنوان
تشکیل موضع هیدروژل های کیتوزان-ژلاتین تزریقی از طریق اتصال دوطرفه برای تحویل مداوم دارو داخل چشم
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کلمات کلیدی
ژل تزریقی کیتوزان، ژلاتین، ژنپین، تحویل داروی داخل چشمی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Rapid clearance and low ocular bioavailability are drawbacks of conventional ophthalmic eye drops. To increase the ocular drug resistance time and improve efficacy, an in situ forming and thermosensitive chitosan-gelatin hydrogel was developed. The feasibility of using this hydrogel as a topical eye drop formulation for sustained release of timolol maleate was evaluated. The flexible hydrogel that was co-crosslinked with βâglycerophosphate disodium salt hydrate (β-GD) and genipin showed a fast gel formation at 37â¯Â°C. The swelling properties and in vitro biodegradation characteristics showed a strong relationship with the initial genipin concentration. In vitro release profiles demonstrated that crosslinking with genipin reduced the release rate of entrapped model drugs and timolol maleate. In vitro cytotoxicity tests showed that the hydrogel was non-toxic to Chinese hamster fibroblast V79 cells. The hydrogel was further applied as eye drop formulations for sustained release of timolol maleate to reduce intraocular pressure (IOP). A fast gel formation was observed after instilling the chitosan-gelatin solution into the lower conjunctival sac of the rabbit eyes, and the in situ formed hydrogels protected the drugs from clearance by tears, and released the drugs in a sustained manner. Furthermore, administration of timolol maleate containing chitosan-gelatin hydrogels showed a long-lasting and effective IOP lowering efficacy for up to 24â¯h compared with the conventional eye drops. These results suggested that β-GD and genipin co-crosslinked chitosan-gelatin hydrogels could be a useful ocular drug delivery platform with enhanced therapeutic effects and reduced side effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 88, 1 July 2018, Pages 1-12
Journal: Materials Science and Engineering: C - Volume 88, 1 July 2018, Pages 1-12
نویسندگان
Yuanhui Song, Nobuhiro Nagai, Saaya Saijo, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe,