کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7869714 | 1509171 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Controlling silk fibroin microspheres via molecular weight distribution
ترجمه فارسی عنوان
کنترل میکروسکپ های فیبرین ابریشم از طریق توزیع وزن مولکولی
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کلمات کلیدی
فیبرن ابریشم، وزن مولکولی، سالم کردن میکروسپرس، قدرت یونیک،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Silk fibroin (SF) microspheres were produced by salting out SF solution via the addition of potassium phosphate buffer solution (K2HPO4-KH2PO4). The morphology, size and polydispersity of SF microspheres were adjusted by changing the molecular weight (MW) distribution and concentration of SF, as well as the ionic strength and pH of the buffer solution. Changing the conditions under which the SF fiber dissolved in the Lithium Boride (LiBr) solution resulted in altering the MW distribution of SF solution. Under optimal salting-out conditions (ionic strength > 0.7 M and pH > 7) and using a smaller and narrower SF MW distribution, SF microspheres with smoother shapes and more uniform sizes were produced. Meanwhile, the size and polydispersity of the microspheres increased when the SF concentration was increased from 0.25 mg/mL to 20 mg/mL. The improved SF microspheres, obtained by altering the distribution of molecular weight, have potential in drug and gene delivery applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 50, 1 May 2015, Pages 226-233
Journal: Materials Science and Engineering: C - Volume 50, 1 May 2015, Pages 226-233
نویسندگان
Dong-Mei Zeng, Jue-Jing Pan, Qun Wang, Xin-Fang Liu, Hui Wang, Ke-Qin Zhang,