Biosynthesis of gold decorated reduced graphene oxide and its biological activities

An eco-friendly, very simple method for synthesis of gold-reduced graphene oxide (Au-rGO) nanocomposite was developed using fruit of Piper pedicellatum C.DC. Its characterization was done by UV-visible, FT-IR, XRD, XPS, Raman, SEM-EDX, TEM analysis. The antibacterial activity of Au-rGO nanoparticles was investigated against the Gram negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and Gram positive bacteria Staphylococcus aureus and Bacillus cereus. In addition, in-vitro cell based cytotoxicity study was performed for Au-rGO and GO against PC3 (aggressive human prostate carcinoma cell line) and RWPE-1(non-malignant human prostate epithelial cells). Cytotoxicity assay revealed that Au-rGO is more toxic than GO nanoparticles against PC3 cancer cells compared to RWPE-1