Multilayer material properties of aorta determined from nanoindentation tests

In a wide range of biomechanical modeling of aorta from traumatic injury to stent grafts, the arterial wall has been considered as a single homogeneous layer vessel, ignoring the fact that arteries are composed of distinct anatomical layers with different mechanical characteristics. In this study, using a custom-made nanoindentation technique, changes in the mechanical properties of porcine thoracic aorta wall in the radial direction were characterized using a quasi-linear viscoelastic model. Two layers of equal thickness were mechanically distinguishable in descending aorta based on the radial variations in the instantaneous Young's modulus E and reduced relaxation function G(t). Overall, comparison of E and G∞ of the outer half (70.27±2.47 kPa and 0.35±0.01) versus the inner half (60.32±1.65 kPa and 0.33±0.01) revealed that the outer half was stiffer and showed less relaxation. The results were used to explain local mechanisms of deformation, force transmission, tear propagation and failure in arteries.

Graphical AbstractFigure optionsDownload high-quality image (221 K)Download as PowerPoint slideHighlights
► Mechanical properties of porcine aorta wall were characterized by nanoindentation.
► Two layers of equal thickness were mechanically distinguishable.
► Outer half was stiffer and showed less relaxation.
► Results explain why tissue mechanical failure starts from inner layer.