کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
811652 906084 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery
ترجمه فارسی عنوان
میکرو محور تومور و نانومواد فعال سیگنال داخل سلولی برای تحویل داروهای ضد سرطان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Cancer-associated stimuli-responsive nanosystems have been increasingly considered for the delivery of anticancer drugs, which primarily target the tumor microenvironment and/or intracellular elements to enhance intratumoral accumulation and promote drug release at the target site. The signals facilitating drug delivery include tumor and endocytic acidities, hypoxia, enzyme overexpression, as well as high levels of intracellular glutathione, reactive oxygen species, and adenosine-5′-triphosphate. This article reviews the current techniques and ongoing developments in anticancer drug delivery using these signals. In particular, the focus is placed on design strategies and methods of formulating novel nanoscaled materials. The merits and drawbacks of recent strategies, as well as potential future developments, are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 19, Issue 5, June 2016, Pages 274–283
نویسندگان
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