کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8131008 | 1523231 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis
ترجمه فارسی عنوان
اعتبار سنجی سونوگرافی اسکلتی عضلانی در ارزیابی سینووییت نقرس تجربی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
The objective of this study was to validate musculoskeletal ultrasound (US) in a rabbit model of acute gout. Acute gout was induced by intra-articular injection of monosodium urate (MSU) crystals in 10 rabbits; the 3 controls received vehicle. Rabbit knees were assessed by B-mode and power Doppler (PD) US 24 and 72âh after injections. After 72âh, all rabbits were euthanized. US discriminated between the MSU-injected and control groups with respect to the different inflammatory findings at both at 24 and 72âh and for MSU crystal-related findings after 24âh of injection. US synovial thickening, intra-synovial power Doppler signal and global joint distension significantly correlated with the synovial global histopathological score (râ=â0.47, pâ=â0.0188), tissue vascularization measured by CD31 immunohistochemical-positive staining (râ=â0.46, pâ=â0.0172) and tissue levels of interleukin-1β (râ=â0.53, pâ=â0.0078), respectively. US is a valid method for assessment of synovial inflammation in experimental gouty arthritis in rabbits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 44, Issue 7, July 2018, Pages 1516-1524
Journal: Ultrasound in Medicine & Biology - Volume 44, Issue 7, July 2018, Pages 1516-1524
نویسندگان
Esperanza Naredo, Juan Pablo Medina, Sandra Pérez-Baos, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo,