Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy

► PDN affects Cav3.2 and TRPV1 channels in small DRG neurons. ► Hyperalgesic PDN upregulated both Cav3.2 and TRPV1 channels. ► Hypoalgesic PDN downregulated Cav3.2 and TRPV1 channels. ► Upregulation of Cav3.2 and downregulation of TRPV1 channels under normalgesic PDN ► Increased T-type window current contributes to the resting [Ca2 +]i in diabetes.