O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

►The levels of O-GlcNAc and OGT were elevated in the lung and colon cancer tissues. ►OGT increase may be a main cause of O-GlcNAc elevation in tumor tissues. ►O-GlcNAc plays important roles in lung and colon cancer malignancy.