کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8287670 | 1535861 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress markers at birth: Analyses of a neonatal population
ترجمه فارسی عنوان
نشانگرهای استرس اکسیداتیو در هنگام تولد: تجزیه و تحلیل جمعیت نوزادان
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کلمات کلیدی
GSSGAGAHspHsp60GPXGSHROS - ROSneonatal stress - استرس نوزادانSOD - سدgestational age - سن حاملگیSuperoxide dismutase - سوکسوکس دیسموتازLOOH - لئوlipid hydroperoxides - هیدروپراکسید لیپیدHeat shock proteins - پروتئینهای شوک حرارتیreduced glutathione - کاهش گلوتاتیونGlutathione - گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شدهglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
In order to further understand neonatal stress and, thus, control it efficaciously, there is a need for more information on the manifestations of stress at the molecular level in the newborn, with particular regard to oxidants, and anti-oxidant and anti-stress mechanisms, including mitochondrial heat shock protein-chaperones such as Hsp60. We investigated patterns of anti-oxidants, biomarkers of oxidative stress, and Hsp60 levels in sera from newborns and found significant associations between glutathione (GSH) levels and gestational age, delivery modality, and lipid hydroperoxydes (LOOH) level. LOOH levels and spontaneous (vaginal) delivery were independently associated with increased GSH levels when these were above the median. Hsp60 and LOOH levels were positively correlated whereas Hsp60 and GSH levels were inversely correlated in spontaneously delivered newborns; in contrast, Hsp60 and GSH levels were positively correlated in newborns delivered by cesarea. Our results point to new directions in the search for definite patterns of GSH, LOOH, and Hsp60 in the newborn's serum that might have functional and diagnostic significance and that could help in the monitoring of newborn health during and after delivery. In addition, the data provide a starting basis for investigating the precise roles and interplay of GSH and Hsp60 in the maintenance of an optimal redox balance at birth to cope with the stress inherent to delivery, and also for investigating the predictive value of any given pattern of GSH, LOOH, and Hsp60 at birth with regard to health status and risk of disease in adult life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 486-491
Journal: Acta Histochemica - Volume 117, Issues 4â5, MayâJune 2015, Pages 486-491
نویسندگان
Mario Giuffrè, Manfredi Rizzo, Giusy Scaturro, Alessandro Pitruzzella, Antonella Marino Gammazza, Francesco Cappello, Giovanni Corsello, Giovanni Li Volti,