Angtensin II elicits a cAMP-dependent intestinal anion secretion by stimulating PGE2 release through AT1 subtype receptors in rat ileum

PGE2 is an inflammatory mediator and PGE2 can stimulate different G proteins, depending on the type of EP subtype engaged, inducing changes in second messengers such as cAMP, Ca2+, and inositol phosphates. After binding to ATR1, AngII increases intracellular level of PGE2 which, in turn, drives Cl− secretion by stimulating cAMP- dependent cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane of intestinal epithelial cells. In addition, COX enzymes involves the AngII-evoked response in rat ileum. Taken together, AngII evokes a secretory response in rat ileum, which is mediated through PGE2 formation via ATR1 and cAMP- dependent Cl− secretion was involved in AngII-induced stimulatory effect.217