کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8321927 1539842 2018 43 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary extracellular vesicle biomarkers in urological cancers: From discovery towards clinical implementation
ترجمه فارسی عنوان
بیومارکرهای بیضه خارج سلولی ادرار در سرطانهای اورولوژی: از کشف به سوی اجرای بالینی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Urine contains cellular elements, biochemicals, and proteins derived from glomerular filtration of plasma, renal tubule excretion, and urogenital tract secretions that reflect an individual's metabolic and pathophysiologic state. Despite intensive research into the discovery of urinary biomarkers to facilitate early diagnosis, accurate prognosis and prediction of therapy response in urological cancers, none of these markers has reached widespread use. Their implementation into daily clinical practice is hampered by a substantial degree of heterogeneity in performance characteristics and uncertainty about reliability, clinical utility and cost-effectiveness, in addition to several technical limitations. Extracellular vesicles (EV) have raised interest as a potential source of biomarker discovery because of their role in intercellular communication and the resemblance of their molecular content to that of the releasing cells. We review currently used urinary biomarkers in the clinic and attempts that have been made to identify EV-derived biomarkers for urological cancers. In addition, we discuss technical and methodological considerations towards their clinical implementation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 99, June 2018, Pages 236-256
نویسندگان
, , , , , , ,