Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice

Effects of SFN on dysregulated metabolic parameters and injury-induced neointima formation in western diet (HFHS)-fed obese C57BL/6 J mice. SFN treatment attenuates weight gain and eWAT weight and improves systemic metabolic abnormalities (e.g., ↓ plasma leptin and insulin, improves HOMA-IR and glucose tolerance, and lowers plasma triglycerides/FFA and systolic blood pressure). In addition, SFN suppresses injury-induced intimal hyperplasia in the femoral artery and inhibits leptininduced VSMC proliferation by targeting p70S6K/S6 signaling. The use of SFN as a dietary supplement may provide a rational prophylactic approach to target restenosis after angioplasty in diet-induced obesity.146