کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8347916 | 1541708 | 2015 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with β-amyloid
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
HOMA-IRGHSR5-bromo-2-deoxyuridineintracerebroventricularICVSTAT-3GSKVCO2OGTTREEVO2Akt - آکتResting energy expenditure - استراحت صرف انرژیstandard deviation - انحراف معیارEnergy - انرژیBrdU - بروموداکسی اوریدینGoat - بزlateral ventricle - بطن جانبیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceoral glucose tolerance - تحمل گلوکز خوراکیCarbon dioxide production - تولید دی اکسید کربنTau - خود راCognitive function - عملکرد شناختیOxygen consumption - مصرف اکسیژنprotein kinase B - پروتئین کیناز BGhrelin - گرلینGhrelin O-acyltransferase - گرلین O-acyltransferaseGlucose - گلوکزglycogen synthase kinase - گلیکوزین سیتستاز کینازgrowth hormone secretagogue receptor - گیرنده ترشح هورمون رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ghrelin is a gastric hormone released during the fasting state that targets the hypothalamus where it induces hunger; however, emerging evidence suggests it may also affect memory function. We examined the effect of central acylated-ghrelin and DES-acetylated ghrelin (native ghrelin) on memory function and glucose metabolism in an experimentally induced Alzheimer's disease (AD) rat model. AD rats were divided into 3 groups and Non-AD rats were used as a normal-control group. Each rat in the AD groups had intracerebroventricular (ICV) infusion of β-amyloid (25-35; 16.8 nmol/day) into the lateral ventricle for 3 days, and then the pumps were changed to infuse either acylated-ghrelin (0.2 nmol/h; AD-G), DES-acylated ghrelin (0.2 nmol/h; AD-DES-G), or saline (control; AD-C) for 3 weeks. The Non-AD group had ICV infusion of β-amyloid (35-25) which does not deposit in the hippocampus. During the next 3 weeks memory function, food intake, body weight gain, body fat composition, and glucose metabolism were measured. AD-C exhibited greater β-amyloid deposition compared to Non-AD-C, and AD-G suppressed the increased β-amyloid deposition and potentiated the phosphorylation AMPK. In addition, AD-G increased the phosphorylation GSK and decreased the phosphorylation of Tau in comparison to AD-C and AD-DES-G. Cognitive function, measured by passive avoidance and water maze tests, was much lower in AD-C than Non-AD-C whereas AD-G but not AD-DES-G prevented the decrease (p < 0.021). Body weight gain was lower in AD-C group than Non-AD-C group without changing epididymal fat mass. AD-G reversed the decrease in body weight which was due to increased energy intake and decreased energy expenditure. The AD-G group exhibited a decrease in the second part of serum glucose levels during an oral glucose tolerance test (OGTT) compared to the AD-C and AD-DES-G group (p < 0.009). However, area under the curve of insulin during the first part of OGTT was higher in AD-DES-G than other groups, whereas during the second part it was suppressed in AD-G as much as Non-AD. In conclusion, central acylated ghrelin in rats prevented the deterioration of memory function, and energy and glucose metabolisms were partially improved, possibly due to less β-amyloid accumulation. This research suggests that interventions such as intermittent fasting to facilitate sustained elevations of acyl-ghrelin should be investigated for cognitive and metabolic benefits, especially in person with early symptoms of memory impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 71, September 2015, Pages 84-93
Journal: Peptides - Volume 71, September 2015, Pages 84-93
نویسندگان
Suna Kang, Na Rang Moon, Da Sol Kim, Sung Hoon Kim, Sunmin Park,