کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8358814 | 1542161 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adipocyte biology in breast cancer: From silent bystander to active facilitator
ترجمه فارسی عنوان
زیست شناسی آدیپوسیت در سرطان سینه: از سرپرست خاموش به تسهیل کننده فعال
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کلمات کلیدی
FABP4ENPP2Tumor-stroma interactionFSPBITCBone marrow adipocyteAutotaxinHGFLPAMCDATXCLSLPCBMATMEEGCGECMADFCAAIGFCAFTNBCMMPmalonyl-CoA decarboxylase - malonyl-CoA dearboxylaseAdipocyte - آدیپوسیتAIF - آیفونepigallocatechin gallate - اپی گالوستاچین گالاتinterleukin - اینترلوکینPAI - باباplasminogen activator inhibitor - بازدارنده فعال کننده پلاسمینوژنWhite adipose tissue - بافت چربی سفیدBenzyl isothiocyanate - بنزیل ایزوتیوسیاناتEMT - تکنسین فوریتهای پزشکیBreast cancer - سرطان پستانTriple-negative breast cancer - سرطان پستان سه گانه منفیapoptosis-inducing factor - عامل القاء آپوپتوزHepatocyte growth factor - عامل رشد هپاتوسیتInsulin-like growth factor - فاکتور رشد مانند انسولینcancer-associated fibroblast - فیبروبلاست وابسته به سرطانLysophosphatidate - لیسففسفیدیداتExtracellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازTumor microenvironment - میکرو محیط زیست تومورfatty acid binding protein 4 - پروتئین اتصال دهنده اسید چرب 4WAT - چیEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Adipocytes account for the largest proportion among the cells that comprise breast tissue; therefore, they are considered to be a critical cell type in the tumor microenvironment of breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but they also play an active role in the entire process of cancer development, progression, metastasis, and treatment response. Factors including the secretion of adipokines such as leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and hepatic growth factor, metabolic remodeling that supports the growth of breast cancer by transfer of fatty acids to increase mitochondrial β-oxidation, extracellular matrix remodeling and endotrophin production from type IV collagen, and cancer-associated fibroblast phenotype changes have all been implicated in this comprehensive process. Moreover, adipocytes may act as obstacles to therapy, as they are involved in mechanisms of resistance against various breast cancer treatments. Adipose tissues may also be a reservoir for dormant tumor cells during postsurgical autologous fat grafting. Thus, adipocytes, and the processes and pathways in which they are involved, could be effective therapeutic targets for breast cancer. In this review, we focus on the current understanding of adipocyte biology as it affects breast cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 69, January 2018, Pages 11-20
Journal: Progress in Lipid Research - Volume 69, January 2018, Pages 11-20
نویسندگان
Junjeong Choi, Yoon Jin Cha, Ja Seung Koo,