TLR4 signaling protects from excessive muscular damage induced by Bothrops jararacussu snake venom

► TLR4-deficient and control mice had similar acute tissue damage after intramuscular injection with Bothrops jararacussu venom. ► TLR4-deficient mice had persistent inflammation, increased MMP9 activity and collagen deposition. ► Lack of TLR signaling delayed resolution of muscular injury. ► TLR4 signaling exerts a protective role in the muscular injury induced by B. jararacussu venom.