کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8435568 | 1546688 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sensitizing tumor cells to radiation by targeting the heat shock response
ترجمه فارسی عنوان
حساس سازی سلول های تومور به اشعه با هدف قرار دادن پاسخ شوک گرما
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کلمات کلیدی
HSEHspHSF1heat shock factor 1 (HSF1)SER - برای بودنRadiosensitization - حساسیت رادیوییheat shock factor 1 - عامل شوک گرما 1heat shock element - عنصر شوک گرماHeat shock protein - پروتئین شوک حرارتHeat shock protein 70 (hsp70) - پروتئین شوک حرارت 70 (hsp70)Heat shock protein 90 (Hsp90) - پروتئین شوک حرارت 90 (Hsp90)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Elevated levels of heat shock proteins (HSPs) contribute to tumor cell survival and mediate protection against radiation-induced cell death. Hsp90 inhibitors are promising radiosensitizers but also activate heat shock factor 1 (HSF1) and thereby induce the synthesis of cytoprotective Hsp70. In this study the heat shock response inhibitor NZ28 either alone or in combination with the Hsp90 inhibitor NVP-AUY922 was investigated for radiosensitizing effects, alterations in cell cycle distribution and effects on migratory/invasive capacity of radioresistant tumor cells. NZ28 reduced the constitutive and NVP-AUY922-induced Hsp70 expression by inhibition of the HSF1 activity and inhibited migration and invasion in human lung and breast tumor cells. Treatment of tumor cells with NZ28 significantly increased their radiation response. One possible mechanism might be a decrease of the radioresistant S-phase. When combined with the Hsp90 inhibitor NVP-AUY922 the concentration of NZ28 could be significantly reduced (1/10th-1/20th) to achieve the same radiosensitization. Our results demonstrate that a dual targeting of Hsp70 and Hsp90 with NZ28 and NVP-AUY922 potentiates the radiation response of tumor cells that are otherwise resistant to ionizing radiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 360, Issue 2, 1 May 2015, Pages 294-301
Journal: Cancer Letters - Volume 360, Issue 2, 1 May 2015, Pages 294-301
نویسندگان
Daniela Schilling, Annett Kühnel, Sarah Konrad, Fabian Tetzlaff, Christine Bayer, Julia Yaglom, Gabriele Multhoff,