Expression of the tetraspanin family members Tspan3, Tspan4, Tspan5 and Tspan7 during Xenopus laevis embryonic development

► Spatiotemporal analysis of Tspan3, Tspan4, Tspan5 and Tspan7 expression patterns. ► Tspan3, Tspan4, Tspan7 exhibit highly similar spatial distribution of gene expression. ► Functions of Tspan3, Tspan4, Tspan7 might be partially redundant. ► Tspan5 expression is restricted to notochord at early stages. ► Tspan5 might play an important role in brain development.