کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478121 | 1550962 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
We have previously reported that Melanocortin 2 receptor (MC2Râ/â) deficient mice on B6 N5 generations exhibited macroscopically detectable adrenal glands with markedly atrophied zona fasciculata (zF) and lack of detectable levels of corticosterone, and reduced serum concentrations of aldosterone and epinephrine. All MC2Râ/â mice on B6/N8 background die within 2 days after birth, while about half of the MC2Râ/â mice on B6/Balbc mix background survived to adulthood. Both male and female MC2Râ/â mice were fertile, suggesting that normal development and function of reproductive organs. MC2Râ/â mice delivered from MC2Râ/â dams failed to survive due to lung failure, suggesting that fetal or maternal corticosterone is essential for lung maturation. MC2Râ/â mice failed to activate the hypothalamic-pituitary-adrenal axis in response to both immune and non-immune stimuli. MC2Râ/â mice maintained glomerular structure and achieved electrolyte homeostasis by the activation of the renin-angiotensin-aldosterone system under low aldosterone and undetectable levels of corticosterone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 300, Issues 1â2, 5 March 2009, Pages 32-36
Journal: Molecular and Cellular Endocrinology - Volume 300, Issues 1â2, 5 March 2009, Pages 32-36
نویسندگان
Dai Chida, Tsuyoshi Sato, Yoshinori Sato, Mitsumasa Kubo, Tetsuya Yoda, Harumi Suzuki, Yoichiro Iwakura,